ACE Clinical Guidances (ACGs)

ACGs* provide concise, evidence-based recommendations to inform specific areas of clinical practice and serve as a common starting point nationally for clinical decision-making. ACGs are underpinned by a wide array of considerations contextualised to Singapore, based on best available evidence at the time of development. Each ACG is developed in collaboration with a multidisciplinary group of local experts representing relevant specialties and practice settings. ACGs are not exhaustive of the subject matter and do not replace clinical judgement. 

Registered doctors, pharmacists and nurses may claim 1 Continuing Medical Education (CME)/Continuing Professional Education (CPE) point under category 3A/ Category V-B for reading each ACG.

*previously known as Appropriate Care Guides

ACG pipeline 

Clinical topics submitted by healthcare professional during our topic open call each year are prioritised based on its potential for impact in evidence-based practice and appropriate care for development into ACG. Upcoming ACG topics in 2025: 1) Chronic coronary disease; 2) Dementia; 3) Generalised anxiety disorder; 4) Major depressive disorder; 5) Smoking cessation; and 6) Osteoporosis. 

Published on 21 Feb 2025
Last Updated on 21 Feb 2025
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This ACE Clinical Guidance (ACG) highlights the importance of consistent support to aid smoking cessation, even for individuals who have previously quit successfully. The ACG provides evidence-based recommendations on advising all smokers on effective methods to help them quit and assessing their willingness to quit, individualised behavioural support and pharmacological treatment, timely follow-up and interventions to prevent relapse. QR codes to I Quit resources are interspersed where appropriate and a handy guide on NRT options is also included.


Download the PDF below to access the ACG.
Registered doctors, pharmacists and nurses may claim 1 Continuing Medical Education (CME)/Continuing Professional Education (CPE) point under category 3A/ 
category V-B for reading each ACG.

ACG recommendations
1.Ask all patients about tobacco use and maintain an up-to-date record of their status.
2.Advise all people who smoke that effective methods to help them quit are available and assess willingness to quit based on their response.
3.Individualise behavioural support to maximise engagement and adherence to the quit plan.
4.Offer combination NRT (long-acting nicotine patch and short-acting NRT) or varenicline, alongside behavioural support.
5.Follow up within the initial weeks after the quit date.
6.Consider interventions to prevent relapse, such as extending pharmacological treatment and advising on coping strategies.

Smoking cessation ACG (Feb 2025) Smoking cessation references (Feb 2025) Smoking cessation EtR framework (Feb 2025)

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