ACE Technology Guidances

ACE Technology Guidances communicate recommendations from the MOH Drug Advisory Committee or the MOH Medical Technology Advisory Committee on the funding status and appropriate use of drugs, vaccines or medical technologies that have been evaluated by ACE. The guidances also include the Committee’s rationale for the funding recommendations, and key clinical and economic evidence which informed their deliberations. Plain English Summaries (PES) to explain ACE Technology Guidances are available for patients and the public.

Published on 04 Jan 2022
Last Updated on 04 Jan 2022
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Guidance Recommendations
The Ministry of Health's Drug Advisory Committee has recommended:
  • Dabrafenib 50 mg and 75 mg capsules in combination with trametinib 0.5 mg and 2 mg tablets for treating locally advanced or metastatic anaplastic thyroid cancer in patients with a BRAF V600 mutation and with no satisfactory locoregional treatment options.

Subsidy status

Dabrafenib 50 mg and 75 mg capsules and trametinib 0.5 mg and 2 mg tablets are recommended for inclusion on the Medication Assistance Fund (MAF) for the abovementioned indication with effect from 4 January 2022.

Clinical indications, subsidy class and MediShield Life claim limits for both drugs are provided in the Annex.


Dabrafenib in combination with trametinib for treating BRAF V600 mutation-positive anaplastic thyroid cancer (4 Jan 2022) PES Dabrafenib in combination with trametinib for treating BRAF V600 mutation-positive anaplastic thyroid cancer (Published 4 Jan 2022)