ACE Technology Guidances communicate recommendations from the MOH Drug Advisory Committee or the MOH Medical Technology Advisory Committee on the funding status and appropriate use of drugs, vaccines or medical technologies that have been evaluated by ACE. The guidances also include the Committee’s rationale for the funding recommendations, and key clinical and economic evidence which informed their deliberations. Plain English Summaries (PES) to explain ACE Technology Guidances are available for patients and the public.

Published on 12 Jul 2022
Last Updated on 01 Sep 2023
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Guidance Recommendations
The Ministry of Health's Drug Advisory Committee has not recommended listing pertuzumab, pertuzumab plus trastuzumab fixed-dose subcutaneous (SC) injection, trastuzumab emtansine or tucatinib on the Medication Assistance Fund (MAF) for treating human epidermal growth factor receptor (HER2)-positive breast cancer due to unfavourable cost-effectiveness at the prices proposed by the manufacturer.

Clinical indications, subsidy class and MediShield Life claim limits for all drugs included in the evaluation are provided in the Annex.

Review of cancer drugs for treating early or advanced HER2-positive breast cancer (Updated 1 Sep 23) Treatments for HER2-positive breast cancer PES (12 Jul 22)